Etymology From the plural of Middle English pocke. See also pock. The curse sense involves metonymy: wishing a literal pox upon someone is the original form of pox-relevant curse, and the word pox itself also came to mean curse.
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A disease characterized by skin eruptions (especially purulent ones) that may leave pockmarks.
A pox on him, he's a cat still.c. 1604–1605 (date written), William Shakespeare, “All’s Well, that Ends Well”, in Mr. William Shakespeares Comedies, Histories, & Tragedies […] (First Folio), London: […] Isaac Iaggard, and Ed[ward] Blount, published 1623, →OCLC, [Act IV, scene iii]:
Etymology From the plural of Middle English pocke. See also pock. The curse sense involves metonymy: wishing a literal pox upon someone is the original form of pox-relevant curse, and the word pox itself also came to mean curse.
Jack had a moſt ſcandalous tongue, and perſuaded Peg that all mankind, beſides himſelf, were pox'd by that ſcarlet-faced whore, †Signiora Bubonia. “As for his brother Lord Peter, the tokens were evident on him, blotches, ſcabs, and the corona. […]”[1750?], Dr. [John] Arbuthnot, “The History of John Bull: Part II, Chapter III”, in The History of John Bull [by Dr. Arbuthnot]. And Poems on ſeveral Occasions by Dr. Jonathan Swift, with Several Miſcellaneous Pieces, by Dr. Swift and Mr. Pope, London: D. Midwinter, A. Tonson, page 60: