gallstone🔊nounUK /ˈɡɔːl.stəʊn/ · US /ˈɡɑːl.stoʊn/Etymology From gall + stone.1Biology, Medicine, Natural sciences, Sciences A small, hard object, in the shape of a pebble, that sometimes forms in the gallbladder or bile duct; composed of cholesterol, bile pigments and calcium salts.Synonymsbilestone, cholelithHypernymscalculus, stone