nondisjunction
nounEtymology From non- + disjunction.
1
Biology, Genetics, Medicine, Natural sciences, Sciences The failure of chromosome dyads or tetrads to separate properly during meiosis or mitosis.
- Different exogenous agents may interfere with the normal disjunction of sister chromosomes during meiosis and increase the frequency of aneuploid sperm, as demonstrated in mice treated with aneugens and men treated with anticancer agents. Although not all germ cells achieve maturity, the close correlation of chromosome nondisjunction in spermatogenesis with genotoxic outcomes indicates that the investigation for aneuploidy in a large sample of aneugen-exposed workers is significant.2004 December 22, Yankai Xia, Senping Cheng, Qian Bian, Lichun Xu, Michael D. Collins, Hebron C. Chang, Lin Song, Jiayin Liu, Shoulin Wang, Xinru Wang, “Genotoxic Effects on Spermatozoa of Carbaryl-Exposed Workers”, in Toxicological Sciences, volume 85, number 1, archived from the original on 24 Dec 2022:
- Derived terms
- nondisjunctional, nondisjunctionally
- Related terms
- disjunction, nondisjunct, nondisjunctive