helix-loop-helix
nounEtymology From helix + loop + helix. The term got its name from its distinct physical geometry; two alpha helices separated and connected by a flexible chain of amino acids known as a "loop", allowing the helices to pack together tightly.
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Biochemistry, Biology, Chemistry, Genetics, Medicine, Microbiology, Natural sciences, Physical sciences, Sciences A structural motif where two alpha helices are connected by a highly flexible amino acid loop, allowing the helices to pack together. Usually requires forming a dimer with another HLH protein before binding DNA.
- Related terms
- helix-turn-helix, heterodimerization, homodimerization, leucine zipper, myogenesis, zinc finger