Etymology Blend of cuckold + quean (“disreputable woman”). The verb sense is derived from the noun sense.
1
Lifestyle, Sexuality A woman who has an unfaithful husband.
Ye make hir a cookqueane.1562, John Heywood, The Proverbs and Epigrams of John Heywood (A.D. 1562), reprint edition, Spenser Society, published 1867, page 62:
Yes, that's her name! His cuckquean she is; his wife she is not and never shall be!1897, William Kirby, “Weird Sisters”, in The Golden Dog, reprint edition (fiction), Echo Library, published 2009, →ISBN, page 289:
2 more examples
A formidable woman of real power and prestige, she emerged from the Monica affair much more cuckold than cuckquean. Her husband’s perfidy did, in a sense, disturb the natural order of things; in the post-feminist age, […]2007 September 13, Judith Warner, “Horned and Scorned”, in The New York Times, New York, N.Y.: The New York Times Company, →ISSN, →OCLC, retrieved 12 Sep 2012:
The rumors about his serial philandering had been out there for years, but a friendly liberal press had not tried very hard to confirm the allegations, and the missus was apparently resigned to the role of a stoic cuckquean.2010, Robert K. Tanenbaum, Betrayed, Simon and Schuster, →ISBN, page 4:
2
A woman who is attracted to or aroused by the sexual infidelity of a partner.