second puberty meaning (slang): definition, quotations

second puberty

noun

Medicine, Sciences Slang The physical, hormonal, and emotional changes that occur in adulthood.

The physical, hormonal, and emotional changes that occur during a hormone replacement therapy.

During gender-affirming hormone therapy, you will go through what is called a “second puberty.” This means that the same emotional struggles that your first puberty may have brought — mood swings, anxiety and depression — are possibilities as an adult during your second puberty.2024 October 25, Helene Frances Hedian, M.D., “Gender-Affirming Hormone Therapy (GAHT)”, in John Hopkins Medicine, archived from the original on 22 Aug 2025: