prototrophy
noun1
Usually The condition of being a prototroph
- Spontaneous mutations in bacteria are generally reversible. Consequently, in a medium where prototrophy confers no selective advantage, various auxotrophs (and other mutant types) should accumulate until for each type the number is such that the loss- by mutation to prototrophy should equal the gain by mutation to the corresponding auxotrophic condition.1951 March, K. C. Atwood, “Periodic Selection in Escherichia Coli”, in Proceedings of the National Academy of Sciences of the United States of America, volume 37, number 3, page 146:
- The pyrG inserted into the gene replacement cassette was amplified from pCDA21 plasmid [40 ] and was used to generate a marker for prototrophy in the mutant strain.2015 August 22, “The Aspergillus fumigatus pkcA G579R Mutant Is Defective in the Activation of the Cell Wall Integrity Pathway but Is Dispensable for Virulence in a Neutropenic Mouse Infection Model”, in PLOS ONE, →DOI:
- Related terms
- prototrophic
- Coordinate terms
- auxotrophy