nociplastic
adjEtymology Blend of nociceptive + neuroplastic, or perhaps noci- + plastic.
1
Medicine, Physiology, Sciences Of, pertaining to, or resulting from plasticity, of a kind analogous to neuroplasticity, in parts of the central nervous system concerned with nociception.
- Patients with rheumatic conditions often have mixed pain states, with varying degrees of nociceptive, neuropathic, and nociplastic mechanisms, which exist on a continuum. When individuals with any chronic pain have a nociplastic component to their symptoms, they are less likely to respond to treatments (eg, injections, surgery, biologics, and opioids) that work better for acute or purely nociceptive pain.2021, Deeba Minhas, Daniel Joseph Clauw, “Pain Mechanisms in Patients with Rheumatic Diseases”, in Maripat Corr, editor, Pain in Rheumatic Diseases, Elsevier, unnumbered page:
- Pain can be classified as nociceptive, neuropathic, or nociplastic as per the International Association for the Study of Pain [6, 7]. Fibromyalgia falls within the nociplastic classification.2023, George Deng, “9: Fibromyalgia”, in Brian W. Blakley, Joan E. Blakley, editors, Functional Illness of the Head and Neck, Springer, page 75:
1 more example
- Peripheral sensitisation of nociceptive neurons can enhance or prolong the pain experience, even without sensitisation of central neurons (i.e. nociplastic or central sensitisation).2024, Elaine Atkins, Emily Goodlad, Sharon Braddock, A Practical Approach to Musculoskeletal Medicine, 5th edition, Elsevier, page 5:
- Derived terms
- nociplastic pain
- Related terms
- nociceptive, nociplasticity