A relatively large dose of (something, such as a drug or radiation), particularly as contrasted with a microdose.
Here macrodose is defined as the average dose for a large-size object such as a liver or a tumour.2002, H. Zaidi, G Sgouros, Therapeutic Applications of Monte Carlo Calculations in Nuclear Medicine, CRC Press, →ISBN:
The mass of non-radiolabeled dose in the total mass administered is selected to meet the aims of the study. The non-radiolabeled dose could be a macrodose (> 100 μg), in designs defined herein as “macrodose with microtracer” studies.2019, Paul G. Pearson, Larry C. Wienkers, Handbook of Drug Metabolism, Third Edition, CRC Press, →ISBN, page 702:
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This is the equivalent of nearly 7 quarts per day for an adult—truly a macrodose! Vomiting, diarrhea, colic, and occult bleeding are symptoms of allergy. It also affects the respiratory tract (runny nose, cough, asthma) and the skin […]2010, Jan Riordan, Karen Wambach, Breastfeeding and Human Lactation, Jones & Bartlett Learning, →ISBN, page 139:
macrodose
verb
Etymology From macro- + dose; contrast microdose.
1
To take a relatively large dose of (something, particularly a drug), particularly as contrasted with microdosing.
Much less expensive than either is macrodosing with vitamins C, D, and E, which has been shown to be beneficial in slowing the progression of osteoarthritis of the knee.2002, Irwin M. Siegel, MD, All About Joints: How to Prevent and Recover from Common Injuries, Demos Medical Publishing, →ISBN, page 16:
(Gasser et al., 2014) While this may have been a factor in our respondents' experiences, we did not ask them if they had macrodosed during their microdosing period.2019, Michael J. Winkelman, Ben Sessa MD, Advances in Psychedelic Medicine: State-of-the-Art Therapeutic Applications, ABC-CLIO, →ISBN, page 330:
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'In which case,' I'd pointed out, 'you're not microdosing at all, you're macrodosing'2020, Rob Doyle, Threshold, Bloomsbury Publishing USA, →ISBN: