jimpy
noun1
Biology, Natural sciences A sex-linked mutation in mice that causes severe hypomyelination in males.
- When cerebellar tissues from normal and Jimpy are grown on the same slide in a common medium, no mutual effects can be observed: the Jimpy does not myelinate, and the normal does not stop myelination.1973, Norbert N. Herschkowitz, “Chapter 4: Genetic Disorders of Brain Development: Animal Models”, in Gerald E. Gaull, editor, Biology of Brain Dysfunction: Volume 2, Plenum Press, page 172:
- 1999, Klaus-Armin Nave, Chapter 2: X-Linked Dysmyelination: Mouse Models of Pelizaeus-Merzbacher Disease, Brian Popko (editor), Mouse Models in the Study of Genetic Neurological Disorders, Kluwer Academic / Plenum Publishers, page 29, The jimpy phenotype is marked by a CNS-specific dysmyelination and has provided an authentic animal model for PMD (Sidman et al., 1964). Typically, 50% of the male progeny of jimpy carrier females are affected, whereas the heterozygous carrier female itself is unaffected.